hiasm guidance- Shh protein is produced by RGCs in the retina and transported to the optic chiasm
- Shh is secreted by contralateral RGCs at the chiasm to repel ipsilateral RGCs
- The repulsive effect of Shh requires the receptor Boc and signaling mediator Smo
- Remotely produced cues and axon-axon interactions are important in chiasm guidance
• The research paper focuses on the role of Shh protein in guiding retinal ganglion cells (RGCs) to their target at the optic chiasm.
• It is found that RGCs produce and secrete this protein, which acts as a repellent for other contralateral RGCs present at the chiasm.
• This repulsive effect requires two components: Boc receptor and Smo signaling mediator.
• Additionally, it has been observed that both remote cues from outside sources and axon-axon interactions are important factors influencing guidance of these cells towards their destination.
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